The tongue-controlled Game Boy Advance
From Simmunity Corporation and newAbilities Systems, a Game Boy Advance SP for quadriplegics (or perhaps anyone able-bodied who wants to give their wrists a rest) that's been modified so it can be controlled using only your tongue. Right now it only works with games that don't require multiple buttons to be pressed at the same time and a few custom-made games.
[Via Slashdot]